The Seed and Soil Hypothesis
The proposal that cancers spread to particular organs not by accident of circulation but because those tissues are hospitable to them. It was…
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The proposal that cancers spread to particular organs not by accident of circulation but because those tissues are hospitable to them. It was…
Cancer cells burn glucose wastefully, converting it to lactate even when oxygen is plentiful. The observation is a century old and undisputed, it is…
Cancer caused by loss of a tumour suppressor requires both copies of the gene to be knocked out. Alfred Knudson deduced this in 1971 from the…
The ordered sequence a cell follows to duplicate itself, controlled by checkpoints that stop it proceeding until the previous stage is complete.…
The proposal that tumours are sustained by a small subpopulation of cells with stem-like properties, and that killing the bulk of a tumour without…