What causes depression and schizophrenia?
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The live hypotheses side by side, from chemical imbalance to inflammation, the gut and social defeat, and why none of them has won yet.
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Depression
Schizophrenia
The biology underneath
Hypothesis
The Serotonin Hypothesis of Depression
Hypothesis
The Inflammatory Hypothesis of Depression
Hypothesis
The Gut-Brain Axis
Theory
The Gut-Brain Axis: Microbiome Influence on Mental Health
Hypothesis
Social Media Use and Adolescent Depression: Causal Relationship Under Investigation
Contested
Why We Sleep
Hypothesis
The Dopamine Hypothesis of Schizophrenia
Hypothesis
The Glutamate Hypothesis of Schizophrenia
Hypothesis
The Social Defeat Hypothesis of Psychosis
Contested
Nature versus Nurture
Fact
Neurotransmitters
Fact
The Neuron
Fact
Inflammation
Theory
Neuroplasticity
Proven
The Blood-Brain Barrier
Hypothesis
The Glymphatic System
Most of these cards are hypotheses. Each explains part of the picture; the likeliest answer is that several causes act together.
Question
Why do treatments that work for some people do nothing for others?